Cytokine IL-6 and IL-10 as Biomarkers in Systemic Lupus Erythematosus |
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Authors: | Hye-Young Chun Jae-Wook Chung Hyoun-Ah Kim Jeong-Moon Yun Ja-Young Jeon Young-Min Ye Seung-Hyun Kim Hae-Sim Park Chang-Hee Suh |
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Institution: | (1) Department of Allergy and Rheumatology, Ajou University School of Medicine, Woncheon-dong, San5, Youngtong-gu, Suwon, 443-721, South Korea |
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Abstract: | There is a great deal of interest in the identification of biomarkers that are closely associated with disease activity in
systemic lupus erythematosus (SLE), but few biomarkers have been validated. Cytokines play an important role in the pathogenesis
of SLE. Therefore, we evaluated the levels of cytokines and their possible association with disease activity. In the present
study, we found that the SLE patients had higher IL-6, IL-10, IL-12, and IFN-γ levels, but lower IL-2, than normal controls.
Serum IL-6 level was significantly elevated in active SLE patients and correlated with the SLE activity index (SLEDAI), erythrocyte
sedimentation rate (ESR), and C-reactive protein (CRP). Serum IL-10 level was also significantly elevated in active SLE patients
and revealed positive correlation with SLEDAI and anti-double-stranded DNA (dsDNA) titer and negative correlation with C3,
C4, and lymphocyte counts. No significant differences in the levels of cytokines were observed between SLE patients with nephritis
and those without nephritis. These data suggest that IL-6 and IL-10 may be a useful biomarker for disease activity in SLE. |
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Keywords: | Systemic lupus erythematosus biomarker cytokines |
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