| 心肌缺血再灌注损伤中细胞焦亡的研究进展 |
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| 引用本文： | 刘成兴,林吉斌,李大主.心肌缺血再灌注损伤中细胞焦亡的研究进展[J].国际免疫学杂志,2021,44(1):71-75. |
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| 作者姓名： | 刘成兴 林吉斌 李大主 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院心内科，武汉 430022 |
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| 基金项目： | 国家自然科学基金(81670404,81700390)。 |
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| 摘 要： | 细胞焦亡是近年来发现并被证实的一种新的细胞程序性死亡方式,它的特征是依赖半胱氨酸天冬氨酸酶1(cysteinyl aspartate specific proteinase 1,caspase-1)并伴随大量炎症因子的释放。细胞焦亡参与了包括感染性疾病在内的多种疾病的病理生理过程。作为一种新的调节性细胞死亡方式,近年来细胞焦亡受到了广泛的关注。新近研究发现,细胞焦亡也参与了心肌缺血再灌注损伤(myocardial ischemia reperfusion injury,MIRI)过程,文章就MIRI中细胞焦亡的研究进展进行综述。
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| 关 键 词： | 细胞焦亡 心肌缺血再灌注损伤 炎性小体 |
Research progress of cell pyroptosis in myocardial ischemia reperfusion injury |
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| Liu Chengxing,Lin Jibin,Li Dazhu.Research progress of cell pyroptosis in myocardial ischemia reperfusion injury[J].International Journal of Immunology,2021,44(1):71-75. |
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| Authors: | Liu Chengxing Lin Jibin Li Dazhu |
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| Institution: | (Department of Cardiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China) |
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| Abstract: | Cell pyroptosis is a newly found mode of regulated cell death and experimentally verified recently.It is characterized by its dependence on cysteinyl aspartate specific proteinase 1(caspase-1)and the release of a large number of inflammatory factors.Pyroptosis is involved in the pathophysiological process of many diseases including infectious diseases.As a new way of regulatory cell death,pyroptosis has attracted extensive attention in recent years.Recent studies have found that it participates in the pathological processes of myocardial ischemia reperfusion injury(MIRI).This review summarized the research progress of cell pyroptosis in MIRI. |
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| Keywords: | Cell pyroptosis Myocardial ischemia reperfusion injury Inflammasome |
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