ki67在三阴性乳腺癌中的临床病理意义

目的 通过检测三阴性乳腺癌中细胞增殖抗原ki67的表达情况,分析其与临床病理特征及预后的关系,明确ki67是否可以作为判断三阴性乳腺癌的预后指标.方法 应用免疫组织化学方法检测ki67在三阴性乳腺癌组织中的表达,分析ki67表达与三阴性乳腺癌患者临床病理特征的相关性及与预后的关系.结果 ki67在三阴性乳腺癌组织中的表达与肿瘤大小、TNM分期、组织学分级和淋巴结转移有关(x2=10.536、16.824、11.020、7.180、P＜0.05).单因素生存分析结果显示:肿瘤大小、临床分期、组织学分级、淋巴结转移和ki67与患者总生存均相关(OR=4.211、3.800、0.288、3.502、2.612,P＜0.05).Cox多因素生存分析显示,淋巴结转移与总生存有一定的相关性(OR=2.768,P＜0.05).结论 ki67表达与三阴性乳腺癌中肿瘤大小、TNM分期、组织学分级和淋巴结转移有关,对于三阴性乳腺癌的预后评估具有一定的价值,可作为评价三阴性乳腺癌预后的候选指标.通过Cox多因素生存分析,淋巴结转移可作为与总生存相关的独立预后因素.

The clinical pathological significance of ki67 in triple negative breast cancer

Objective To investigate the expression of proliferation cell antigen ki67 in triple negative breast cancer a.nd to analyze its relationship to clinicopathological features and prognosis.Methods Immunohistochemistry was used to detect the expression of ki67 in triple negative breast cancer tissues.Associations between the expression of ki67 and various clinicopathological characteristics as well as survival status were analysed.Result ki67 expression was significantly associated with tumor size,TNM stage,histological grade and lymph node metastasis in triple negative breast cancer(x2 =10.536,16.824,11.020,7.180,P ＜ 0.05).Univariate survival analysis showed that tumor size,clinical stage,histological grade,lymph node metastasis and ki67 were associated with overall survival (OR =4.211,3.800,0.288,3.502,2.612,P ＜ 0.05).Using multivariate analysis,we found that lymph node metastasis was an independent prognostic factor(P ＜ 0.05,OR =2.768).Conclusion The expression of ki67 was correlated with TNM staging,tumor size,histological grading and lymph node.It has a certain value in assessing the prognosis of the triple negative breast cancer,which might be used as a candidate prognostic indicator.Multivariate analysis indicated that lymph node metastasis was an independent prognostic factor in patients with triple negative breast cancer.