T细胞与类风湿性关节炎

类风湿性关节炎(RA)是一种慢性、炎症性自身免疫性疾病,发病机制非常复杂,至今尚未阐明.尽管多种免疫细胞和分子被证实参与了RA的关节炎症反应和组织破坏,但抗原特异性T细胞的激活始终被认为是RA发病起始和进展的中心环节.不同亚群T细胞在RA发病中发挥不同作用,以往认为,自身抗原诱导的促炎性Th1细胞活化是RA发病的主要因...

T cells and rheumatoid arthritis

Rheumatoid arthritis ( RA) is a chronic inflammatory autoimmune disease of unknown etiology. Although a variety of cells and molecules are recognized as contributors to the inflammation and the progressive joint destruction, self-reactived T cell activation is always thought to be a central event in the initiation and progression of this disease. Various subtypes of T cells play a variety of roles in the pathogenesis of RA. In general, CD4 + T cells are recognized to drive the inflammatory response as activated proinflammatory Th1 effector cells. However, recent studies of the role certain T cell subsets, such as regulatory T cells or the newly discovered Th17 cell, suggest an broader involvement of T cells in the pathogenesis of RA and provide new opportunities for the development of innovative therapeutic approaches in the treatment of RA.