Frequency,virulence factors and antifungal susceptibility of Candida parapsilosis species complex isolated from patients with candidemia in the central region of Argentina |
| |
Authors: | C Vigezzi PA Icely C Dudiuk E Rodríguez MS Miró GDV Castillo AI Azcurra C Abiega JP Caeiro FO Riera G García-Effrón CE Sotomayor |
| |
Institution: | 1. Laboratorio de Inmunidad Innata a Patógenos Fúngicos. Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina;2. Centro de Investigaciones en Bioquímica Clínica e Inmunología, CIBICI-CONICET, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina;3. Laboratorio de Micología y Diagnóstico Molecular, Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina;4. Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Santa Fe, Argentina;5. Departamento de Biología Bucal, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina;6. Sección de Enfermedades Infecciosas, Hospital Privado Universitario de Córdoba, Córdoba, Argentina;7. Departamento de Infectología, Sanatorio Allende Córdoba, Córdoba, Argentina |
| |
Abstract: | PurposeOur objectives were to report species distribution and survival of patients with candidemia in Argentina's central region and to establish the prevalence of C.parapsilosis sensu lato species, their virulence factors and their antifungal susceptibility profiles.MethodsYeasts isolated from bloodstream infections in Córdoba (Argentina) (n = 35) were molecularly identified. The production of lipase and acid aspartic protease (Sap), the adhesion capacity, and the isolates’ ability to form biofilm were evaluated. The in vitro activity of 7 antifungal drugs was evaluated (CLSIdocument M27-4thed).ResultsC. albicans was the most prevalent species (48.57%) followed by C. parapsilosis sensu lato (28.57%). The 30-day survival rate for C. albicans candidemia was slightly lower than non-albicans blood infections (50.00% vs. 57.90%). C. parapsilosis sensu stricto and C. orthopsilosis account for 60% and 40% of the cryptic species. Sap production and biofilm formation capacity were higher in C. parapsilosis sensu strico than in C.orthopsilosis. All the strains were susceptible to caspofungin (CAS), anidulafungin (AFG), amphotericin B (AMB), posaconazole (POS) and voriconazole (VRC). Azoles were the most potent agent against C. parapsilosis sensu lato followed by echinocandins and AMB. There were no differences between MICs for fluconazole, VRC, POS and AMB. Contrarily, C. parapsilosis sensu stricto strains showed lower MIC than C. orthopsilopsis isolates for itraconazole and higher MIC values for echinocandins (P < 0.01).ConclusionsWe report a high frequency of isolation of C.orthopsilosis in candidemia patients of central region. Data on the prevalence, virulence capability and antifungal susceptibility of C. parapsilosis complex provide new epidemiological information about these cryptic species in Argentina. |
| |
Keywords: | Corresponding author Haya de la Torre y Medina Allende Ciudad Universitaria Inmunología Departamento de Bioquímica Clínica CIBICI-CONICET 5000 Córdoba Argentina Molecular typing Virulence factors Antifungal susceptibility |
本文献已被 ScienceDirect 等数据库收录! |
|