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关于患者喉部增生肉芽组织摘除术的空气动力学分析
引用本文:江晨,孙亿民,李振潇,张翼飞,张治国,邓林红.关于患者喉部增生肉芽组织摘除术的空气动力学分析[J].生物医学工程研究,2017(1):23-27.
作者姓名:江晨  孙亿民  李振潇  张翼飞  张治国  邓林红
作者单位:常州大学 生物医学工程与健康科学研究院 常州市呼吸医学工程重点实验室,江苏 常州,213164
基金项目:国家自然科学基金资助项目(11472062
摘    要:基于计算流体动力学(computational fluid dynamics,CFD)方法分析咽喉部阻塞患者手术摘除增生肉芽组织前后咽、喉及气道内相关空气动力学指标的变化及其对流场特征的影响,以期为术后临床效果的评估提供理论依据。首先通过患者手术前后的CT影像学数据,建立咽部、喉部及气道的三维有限元数值模型;然后采用计算流体动力学的方法,数值模拟并分析喉部肉芽组织摘除术前后咽、喉及气道内空气动力学特征的变化。结果显示:术后喉部异常结构形态改善显著,气道阻力下降明显,患者呼吸困难的症状在很大程度上得到了缓解。但由于术后患者喉部解剖结构的变化,使得患者吸气时出现气流扰动及局部负压的情况。这些结果表明通过对咽、喉及气道内空气动力学的分析研究,有助于找出造成空气动力学异常的关键解剖结构,咽喉及气道内流场的CFD数值模拟分析可以有效地评估喉部增生肉芽组织摘除术的临床效果。为开展个性化咽喉部阻塞治疗术提供更多的理论依据。

关 键 词:肉芽组织  摘除术  喉部  计算流体动力学  评估

Aerodynamic Analysis of Hyperplastic Granulation Tissue Excision in Larynx
JIANG Chen,SUN Yimin,LI Zhenxiao,ZHANG Yifei,ZHANG Zhiguo,DENG Linhong.Aerodynamic Analysis of Hyperplastic Granulation Tissue Excision in Larynx[J].Journal Of Blomedical Englneerlng Research,2017(1):23-27.
Authors:JIANG Chen  SUN Yimin  LI Zhenxiao  ZHANG Yifei  ZHANG Zhiguo  DENG Linhong
Abstract:To investigate the change in aerodynamic indexes in patient's pharynx, larynx and trachea after hyperplastic granulation tissue excision, computational fluid dynamic (CFD) analyses were performed, which may provide a theoretical basis for the evaluation of postoperative effect.Firstly, three-dimensional finite element models of the pharynx, larynx and trachea before and after operation were established based on the patient's CT imaging.Then, the numerical simulations based on CFD methods were performed to investigate the change in aerodynamic indexes in patient's pharynx, larynx and trachea after hyperplastic granulation tissue excision.Numerical simulation results indicated that the dyspnea symptom of patient was largely alleviated after operation, the abnormal laryngeal morphology was obviously improved and the resistance of laryngeal and trachea was decreased significantly.However, the air flow disturbance and local obvious negative pressure were happened as the patient inhale, for the reason of changed anatomy of patient's larynx and trachea geometric model.Present research demonstrates nthat the CFD can be used to evaluate the postoperative effect of hyperplastic granulation tissue excision.The aerodynamic analysis on pharynx, larynx and trachea contributes to locate the key anatomical structure which caused air flow abnormalities and provide more theoretical basis for the development of personalized treatment on larynx obstruction.
Keywords:Granulation tissue  Excision  Larynx  Computational Fluid Dynamics  Evaluation
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