Evaluation of a bioceramic-based nanocomposite material for controlled delivery of a non-steroidal anti-inflammatory drug |
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| Authors: | S Hesaraki F Moztarzadeh N Nezafati |
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| Institution: | 1. Ceramics Department, Materials & Energy Research Center, Tehran 14155/4777, Iran;2. Department of Biomaterials, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran;1. Resident, Center of Implant Dentistry, Hospital of Stomatology, Tongji University, Shanghai, China;2. Resident, Center of Implant Dentistry, Hospital of Stomatology, Tongji University, Shanghai, China;3. Professor, Center of Implant Dentistry, Hospital of Stomatology, Tongji University, Shanghai, China;1. Laboratory of Cell Biology, Rostock University Medical Center, Schillingallee 69, 18057 Rostock, Germany;2. DOT GmbH, 18059 Rostock, Germany;3. Institute of Medical Microbiology, Virology and Hygiene, Rostock University Medical Center, 18057 Rostock, Germany;4. Department of Orthopaedics, Biomechanics and Implant Technology Research Laboratory, Rostock University Medical Center, 18057 Rostock, Germany;1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China;2. Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China;3. Department of Orthodontics, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, China;4. Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Hawthorn, Vic 3122, Australia;1. School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, GPO Box 2434, Brisbane, Queensland 4001, Australia;2. Geology Department, School of Mines, Federal University of Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, MG, 35400-00, Brazil;3. Mining Engineering Department, School of Mines, Federal University of Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, MG, 35400-00, Brazil |
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| Abstract: | In this study, nanocomposite of 50 wt% calcium sulfate and 50 wt% nanocrystalline apatite was produced and its biocompatibility, physical and structural properties were compared with pure calcium sulfate (CS) cement. Indomethacin (IM), a non-steroidal anti-inflammatory drug, was also loaded on both CS and nanocomposite cements and its in vitro release was evaluated over a period of time. The effect of the loaded IM on basic properties of the cements was also investigated. Biocompatibility tests showed a partial cytotoxicity in CS cement due to the reduced number of viable mouse fibroblast L929 cells in contact with the samples as well as spherical morphologies of the cells. However, no cytotoxic effect was observed for nanocomposite cement and no significant difference was found between the number of the cells seeded in contact with this specimens and culture plate as control. Other results showed that the setting time and injectability of the nanocomposite cement was much higher than those of CS cement, whereas reverse result obtained for compressive strength. In addition, incorporation of IM into compositions slightly increased the initial setting time and injectability of the cements and did not change their compressive strength. While a fast IM release was observed from CS cement in which about 97% of the loaded drug was released during 48 h, nanocomposite cement showed a sustained release behavior in which 80% of the loaded IM was liberated after 144 h. Thus, the nanocomposite can be a more appropriate carrier than CS for controlled release of IM in bone defect treatments. |
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