| 干细胞诱导形成软骨细胞研究进展 |
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| 引用本文： | 谢峰,张文杰,曹谊林.干细胞诱导形成软骨细胞研究进展[J].国际生物医学工程杂志,2006,29(3):138-141. |
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| 作者姓名： | 谢峰 张文杰 曹谊林 |
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| 作者单位： | 200011,上海第二医科大学附属第九人民医院整形外科,上海市组织工程研究与开发中心 |
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| 基金项目： | 国家重点基础研究发展计划(973计划)基金资助项目(2005CB522705) |
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| 摘 要： | 组织工程技术构建软骨需要大量的软骨细胞,成熟的软骨细胞扩增能力有限,难以满足组织构建需要。干细胞,包括胚胎干细胞、成体干细胞,均具有强大的自我更新能力及多向分化潜能。在适当的诱导条件下,这些干细胞均可被诱导分化为软骨细胞,从而满足组织工程需求。
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| 关 键 词： | 胚胎干细胞 骨髓基质干细胞 脂肪干细胞 软骨细胞 分化 |
| 文章编号： | 1673-4181(2006)03-0138-04 |
| 修稿时间： | 2005年9月30日 |
Progress of studies on chondrogenic differentiation from stem cells |
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| XIE Feng,ZHANG Wen-jie,CAO Yi-lin.Progress of studies on chondrogenic differentiation from stem cells[J].International Journal of Biomedical Engineering,2006,29(3):138-141. |
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| Authors: | XIE Feng ZHANG Wen-jie CAO Yi-lin |
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| Institution: | XIE Feng.ZHANG Wen-jie.CAO Yi-lin.Department of Plastic and Reconstructive Surgery.The Ninth People Hospital of Shanghai Second Medical University.Shanghai Tissue Engineering Development and Research Center.Shanghai 200011.China |
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| Abstract: | Large quantity of chondrocytes is required for cartilage tissue engineering.Matured chondrocytes are not suitable for tissue,engineering due to their limited proliferating potential.Stem cells.including embryonic stem cell and adult stem cell.have strong potential for self,renewing and multi,lineage differentiation.They can be differentiated into chondrocytes when cultivated in the presence of proper inducers.therefore.meet the demand of cartilage tissue,engineering. |
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| Keywords: | embryonic stem cell bone marrow stromal cells adipose derived stem cell chondrocyte differentiation |
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