| 基于RP的组织工程细胞外基质--载体制造问题研究 |
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| 引用本文： | 吴永辉,李涤尘,卢秉恒,王臻.基于RP的组织工程细胞外基质--载体制造问题研究[J].国际生物医学工程杂志,2001,24(3):102-107. |
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| 作者姓名： | 吴永辉 李涤尘 卢秉恒 王臻 |
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| 作者单位： | 1. 西安交通大学先进制造研究所,
2. 第四军医大学, |
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| 基金项目： | 国家自然科学基金资助项目(59975074);高等学校优秀青年教师教学和奖励基金资助项目 |
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| 摘 要： | 针对组织工程中急需具有适当尺寸的孔隙及孔隙度结构的细胞外基质-载体和组织载体的骨架材料的问题,本文引入了目前正在飞速发展的快速成形(RP)技术.应用这种技术可以在短时间内制出既具有精确解剖学形态、又具有适当尺寸的孔隙及孔隙度的三维立体结构的支架.它可以控制载体骨架材料内部微孔的数量、大小、分布及形状,从而提供给细胞的生存以最适宜的空间和营养条件.
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| 关 键 词： | 组织工程 快速成形技术 细胞外基质 人工骨 |
| 文章编号： | 1001-1110(2001)03-0102-06 |
| 修稿时间： | 2000年12月13 |
The research on ECM fabrication of tissue engineering based on RP |
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| WU Yong hui ,LI Di chen ,LU Bing heng ,WANG Zhen.The research on ECM fabrication of tissue engineering based on RP[J].International Journal of Biomedical Engineering,2001,24(3):102-107. |
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| Authors: | WU Yong hui LI Di chen LU Bing heng WANG Zhen |
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| Institution: | WU Yong hui 1,LI Di chen 1,LU Bing heng 1,WANG Zhen 2 |
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| Abstract: | According to the problems existing in ECM fabrication of tissue engineering there is an urgent need for ECM scaffold with suitable pore dimensions and porosity.A newly developed technique Rapid Prototyping is reported.Adopting this technique,a three dimensional scaffold that has accurate anatomy contour and suitable pore dimensions and porosity can be fabricated in a short time.The most important characteristic of this technique is that the quantity,size,distribution and shape of micro pores can be affected and controlled.Thereby it can provide optimum space and culturing condition for cell's seeding and growth. |
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| Keywords: | tissue engineering rapid prototyping extracellular matrix(ECM) artificial bone |
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