BODIPY光敏药物在牙齿美白上的应用研究

目的探讨氟化硼络合二吡咯甲川（BODIPY）光敏药物结合光动力治疗（PDT）在牙齿美白的应用及对牙齿表面釉质的影响。方法人离体牙分别经过氧化氢和BODIPY光敏药物光动力美白处理后，使用vita比色板和扫描电镜观察，分析不同方法对牙齿的美白效果及美白前后牙齿表层釉质在晶体和丑微结构上发生的改变。结果经过美自处理前后进行对比，过氧化氢法美白效果显著，但牙齿表面釉质出现严重脱矿现象；BODIPY光敏药物PDT法的美白效果良好，牙齿光滑，牙齿表面有再矿化现象。结论利用BODIPY光敏药物的PDT法对牙齿具有一定的美白效果，并能促进牙齿表面釉质的再矿化，有望成为牙齿美白的新方法。

Application of BODIPY for tooth whitening as a photosensitive drug

Objective To study the tooth whitening effect of boron-dipyrromethene （BODIPY） as a photosen- sitive drug combining photodynamie therapy （PDT） and the influence on the surface of the enamel. Methods After oxidation of hydrogen peroxide or BODIPY by photodynamic therapy, the extracted teeth were evaluated by Vita shade guides matching. The change of surface enamel on the crystals and mierostructure was observed by scanning electron microscopy （SEM）. Results The teeth treated with BODIPY by PDT were smooth and whitened with the remineralization of teeth surface in morphology. While the teeth treated with hydrogen peroxide were whitened obviously but the surface morphology of the teeth was demineralized seriously. Conclusion The results suggest that PDT is effective for teeth whitening and can promote the remineralization of teeth surface enamel with BODIPY as a photosensitive drug. PDT is expected to become a new method for tooth whitening.