| 聚乙烯亚胺纳米粒制备及其应用的研究进展 |
| |
| 引用本文： | 李婷,王海杰,谭玉珍.聚乙烯亚胺纳米粒制备及其应用的研究进展[J].国际生物医学工程杂志,2011,34(4):218-221,226. |
| |
| 作者姓名： | 李婷 王海杰 谭玉珍 |
| |
| 作者单位： | 复旦大学上海医学院人体解剖与组织胚胎学系, 上海,200032 |
| |
| 基金项目： | 国家自然科学基金资助项目 |
| |
| 摘 要： | 基因治疗已经成为现代医疗中极具发展潜力的治疗手段。选择合适的运转载体是基因治疗成功与否的关键之一。尽管病毒载体转染效率很高，但是其免疫源性和安全性等问题限制了它的应用。通过化学反应制备而成的纳米粒作为非病毒转染载体有效解决了上述问题，从而提高了基因转染效率。近年来，大量的研究表明以聚乙烯亚胺为基础的纳米粒已经成为基因转...
|
| 关 键 词： | 聚乙烯亚胺 纳米粒 转染载体 |
Research progress of preparation and application of polyethyleneimine nanoparticles |
| |
| LI Ting,WANG Hai-jie,TAN Yu-zhen.Research progress of preparation and application of polyethyleneimine nanoparticles[J].International Journal of Biomedical Engineering,2011,34(4):218-221,226. |
| |
| Authors: | LI Ting WANG Hai-jie TAN Yu-zhen |
| |
| Institution: | ( Department of Anatomy, Histology and Embryology, Shanghai Medical School of Fudan University, Shanghai 200032, China) |
| |
| Abstract: | Gene therapy has been widely explored as a promising therapeutic tool in modem medical treatment. It is one of key steps for gene therapy to choose efficient carrier. In spite of the high transfection efficiencies of viral vectors, their utilization has been impaired due to immunogenicity and safety. Nanoparticles made by chemical reaction act as non-viral vector, which solved above-mentioned problems, enhanced efficiency of gene transfection. In recent years, polyethyleneimine-based nanoparticles have become ideal carriers in the research of gene transfection, drug controlled release system and cell biology. This review focuses on properties,preparation and application of nanoparticles based on polyethyleneimine. |
| |
| Keywords: | Polyethyleneimine Nanoparticles Carrier |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
