力学载荷对破骨细胞凋亡的影响及其调节机制

破骨细胞是参与骨代谢的基本功能细胞之一.破骨细胞在骨重建过程中主要承担旧骨组织的破坏和吸收,因此,破骨细胞凋亡的微小变化都可能会改变骨重建的进程.调节破骨细胞凋亡的因素有很多,如雌激素、二磷酸盐等生物化学因素,但力学载荷对于破骨细胞生物学活性影响的研究相对较少.综述了力学载荷对破骨细胞生物学活性的影响以及细胞凋亡与破骨细胞凋亡的调节.

Effect of mechanical loading on osteoclast apoptosis and its regulation mechanisms

Osteoclast is one of the basic function cells involved in bone metabolism during the process of bone remodeling. Osteoclasts are responsible for destruction and absorption of the old bone tissue. Thus, a tiny change of osteoclast apoptosis may change the process of bone remodeling. Osteoclast apoptosis is regulated by many factors including estrogen, bisphosphonates and so on. However, fewer researches on effect of mechanical loading on the biological activity of osteoclasts has been carried out. In this paper, the effect of mechanical loading on the biological activity of osteoclasts and its regulation on apoptosis of cells and osteoclast are reviewed.