| 去甲二氢愈创木酸对人恶性胶质瘤细胞系SHG—44生长和分化的… |
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| 引用本文： | 卞修武,史景泉.去甲二氢愈创木酸对人恶性胶质瘤细胞系SHG—44生长和分化的…[J].中华病理学杂志,1997,26(5):285-288. |
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| 作者姓名： | 卞修武 史景泉 |
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| 摘 要： | 目的 探讨去甲二氢愈创木酸对胶质瘤生长和分化的作用及可能机理。结论 ＮＤＧＡ对恶性胶质瘤细胞具有抑制生长和诱导分化作用，对血管生成因子表达亦有抑制作用。
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| 关 键 词： | 神经胶质瘤 细胞分化 去甲二氢 愈创木酸 |
Effects of nordihydroguaiaretic acid on the growth and differentiation of SHG-44 glioma cell line] |
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| X Bian,J Shi,R Xin.Effects of nordihydroguaiaretic acid on the growth and differentiation of SHG-44 glioma cell line][J].Chinese Journal of Pathology,1997,26(5):285-288. |
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| Authors: | X Bian J Shi R Xin |
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| Institution: | Department of Pathology, Third Military Medical University, Chongqing. |
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| Abstract: | OBJECTIVE: To investigate the effects of nordihydroguaiaretic acid (NDGA) on the growth and differentiation of glioma cells and their mechanism. METHODS: A human glioblastoma cell line (SHG-44) was treated with NDGA in the medium or intracytoplasmic microinjection of NDGA. Changes of the growth, morphology, cell cycle and immunohistochemical features of the cell were investigated. RESULTS: It was found that the growth rates and proliferation activity were inhibited by 100 mumol/L NDGA in the medium, with cell cycles altered. NDGA could induce differentiation of these cells with the glial filaments increased, and the treated cells expressed more GFAP but less vimentin. The expression of p53 and bFGF were also decreased. Furthermore, the result of microinjection (1.5 x 10(-11) g/cell) showed similar but more rapid and permanent effects on the glioma cells. CONCLUSION: NDGA has multiple effects of growth inhibition, differentiation therapy, as well as angiosuppression on human glioblastoma cells. |
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