| 血清中MC5-Ag检测对大肠癌的诊断价值 |
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| 引用本文： | 李维雄,牟震先,吴觉平,樊代明,张学庸.血清中MC5-Ag检测对大肠癌的诊断价值[J].细胞与分子免疫学杂志,1993(4). |
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| 作者姓名： | 李维雄 牟震先 吴觉平 樊代明 张学庸 |
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| 作者单位： | 西安空军医院消化内科，第四军医大学西京医院消化实验室，第四军医大学西京医院消化实验室，第四军医大学西京医院消化实验室，第四军医大学西京医院消化实验室 西安 710032，西安 710032，西安 710032，西安 710032 |
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| 摘 要： | MC5是由本实验室建立的鼠抗人结肠癌单克隆抗体,已证实在消化道肿瘤的免疫组化诊断中有较高价值。本文采用MC5和刀豆素A(Con-A)建立的McAb-Con-A ELISA方法,对108例消化道肿瘤患者血清中MC5-Ag水平进行检测。结果表明大肠癌的阳性率为58％,消化道其它恶性肿瘤的阳性率为37％,经U检验分析两组间存在显著性差异。消化道良性疾病的阳性率为10％。MC5-Ag对大肠癌诊断的敏感性和特异性较高,是具有临床应用价值的新型大肠癌血清标志物。
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| 关 键 词： | 消化道肿瘤 抗体 单克隆 免疫学诊断 |
Diagnostic Significance of Serum MC5-Ag in Patients With Gastrointestinal Cancer |
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| Li Weixiong Mu Zhenxian Wu Jueping Fan Daiming Zhang Xueyong.Diagnostic Significance of Serum MC5-Ag in Patients With Gastrointestinal Cancer[J].Journal of Cellular and Molecular Immunology,1993(4). |
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| Authors: | Li Weixiong Mu Zhenxian Wu Jueping Fan Daiming Zhang Xueyong |
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| Abstract: | Murine monoclonal antibody MC5 against human colonic cancer is a valuable marker for immunohistochemical diagnosis of colorectal cancer. In the present study, the authors measured serum MC5 level in 108 patients with gastrointestinal cancer using McAb-Con A ELISA method. The results indicated that the positive rate of colorectal cancer, other gastrointestinal cancers and benign digestive diseases was 58% ( 20/40 ), 37% ( 25/60) and 10% (2/20), respectively and a significant difference was noted among them (p<0.05). The findings demonstrate that MC5-Ag is a sensitive,specific and novel tumor marker and may be a potential valuable marker in clinical diagnosis of colorectal cancer. |
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| Keywords: | antibody monoclonal cancer colorectal immunodiagnosis |
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