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| PRMT5在肿瘤中的作用及其调控机制的研究进展 | |
| 引用本文： | 张还添,王华东,查振刚.PRMT5在肿瘤中的作用及其调控机制的研究进展[J].中国病理生理杂志,2016,32(4):752-758. |
| 作者姓名： | 张还添 王华东 查振刚 |
| 作者单位： | 1. 暨南大学附属第一医院骨关节科, 广东 广州 510632; 2. 暨南大学骨科疾病研究所, 广东 广州 510632; 3. 暨南大学医学院病理生理学系, 广东 广州 510632 |
| 基金项目： | 广州市科技计划(No.2014Y2-00084) |
| 摘 要： | |
| 关 键 词： | 蛋白质精氨酸甲基转移酶5 肿瘤 |
| 收稿时间： | 2015-10-12 |
Role and regulatory mechanism of PRMT5 expression in tumors |
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| ZHANG Huan-tian,WANG Hua-dong,ZHA Zhen-gang.Role and regulatory mechanism of PRMT5 expression in tumors[J].Chinese Journal of Pathophysiology,2016,32(4):752-758. | |
| Authors: | ZHANG Huan-tian WANG Hua-dong ZHA Zhen-gang |
| Institution: | 1. Department of Bone and Joint Surgery, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China; 2. Institute of Orthopedic Diseases, Jinan University, Guangzhou 510632, China; 3. Department of Pathophysiology, Medical College, Jinan University, Guangzhou 510632, China |
| Abstract: | Protein arginine methyltransferases(PRMTs) play crucial roles in the methylation of a series protein substrates. PRMT5 is a type Ⅱ methyltransferase that symmetrically methylates arginine residues of histone and non-histone substrates, thereby regulating a variety of cellular processes through epigenetic control of target gene expression or post-translational modification of signaling molecules. Recently, accumulated evidence has suggested that PRMT5 may function as an oncogene. This review is aimed to summarize the oncogenic role of PRMT5 and its regulatory mechanisms in tumors. |
| Keywords: | PRMT5 Tumors |
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