| PML翻译后修饰在肿瘤细胞中的研究进展 |
| |
| 引用本文： | 黄倩,林雪平,潘巍巍,刘胜兵.PML翻译后修饰在肿瘤细胞中的研究进展[J].中国病理生理杂志,2017,33(8):1532-1536. |
| |
| 作者姓名： | 黄倩 林雪平 潘巍巍 刘胜兵 |
| |
| 作者单位： | 嘉兴学院医学院, 浙江 嘉兴 314001 |
| |
| 基金项目： | 国家自然科学基金资助项目（No.81402162）;浙江省大学生科研创新团队资助项目（"新苗人才计划";No.2016R417026） |
| |
| 摘 要： | <正>早幼粒细胞白血病(promyelocytic leukemia,PML)基因最初被发现于急性早幼粒细胞白血病(acute promyelocytic leukemia,APL)中,在大部分APL病例中发现染色体异位t(15;17),即17号染色体上的维甲酸受体α(retinoic acid receptorα,RARα)基因与位于15号染色体上的PML基因相互异位,产生新的融合蛋白PML-RARα,这种融合蛋白在APL中发挥重要的作用1]。PML蛋白又称TRIM19,属于
|
| 关 键 词： | PML蛋白 PML核小体 SUMO化 磷酸化 |
| 收稿时间： | 2017-03-24 |
Progress of PML post-translational modifications in tumor cells |
| |
| HUANG Qian,LIN Xue-ping,PAN Wei-wei,LIU Sheng-bing.Progress of PML post-translational modifications in tumor cells[J].Chinese Journal of Pathophysiology,2017,33(8):1532-1536. |
| |
| Authors: | HUANG Qian LIN Xue-ping PAN Wei-wei LIU Sheng-bing |
| |
| Institution: | School of Medicine, Jiaxing University, Jiaxing 314001, China |
| |
| Abstract: | The promyelocytic leukemia (PML) protein is an important part of the PML nuclear bodies (PML-NBs) structure.PML protein is crucial for the assembly of PML-NBs and recruits more than 30 different proteins,including DAXX,ATRX,and small ubiquitin-like molecules involving SUMO to the PML-NBs region.Increased evidence has emerged that a number of different proteins is involved in regulating PML activities by post-translational modifications,such as SUMO modification,ubiquitination and phosphorylation.Here,we review recent studies on the combination of PML and different proteins in the process of apoptosis,replicative senescence and DNA damage response. |
| |
| Keywords: | PML protein PML nuclear bodies SUMOylation Phosphorylation |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国病理生理杂志》浏览原始摘要信息 |
| 点击此处可从《中国病理生理杂志》下载免费的PDF全文 |
|
