地尔硫卓对失血性休克犬肝、胰、小肠组织的保护作用（英文）

目的：探讨钙拮抗剂地尔硫卓（Diltiazem, Dil）对失血性休克犬肝、胰、小肠组织的保护作用及机理。方法：犬股动脉放血，平均动脉压（mean artery pressure, MAP）降至5.33-6.67 kPa（40-50 mmHg），分别输Dil和生理盐水。休克90 min时将放出的血液全部回输。整个实验观察240 min。结果：从150 min到240 min，Dil明显提高MAP（P<0.01）；降低肝、胰、小肠组织中丙二醛（malondialdehyde, MDA）含量（P<0.01）；胰腺组织超氧化物歧化酶（SOD）活性升高。电镜显示：使用Dil后，休克犬肝、胰、小肠组织结构正常。结论：在犬失血性休克中，钙拮抗剂Dil能保护肝、胰、小肠组织结构和功能的完整性。

Protective effects of diltiazem on liver, pancreas and small intestine in hemorrhagic-shock canine

AIM: To investigate the protective effects of diltiazem (Dil) on liver, pancreas and small intestines in hemorrhagic-shock canines and its mechanism. METHODS: The canines were bled to a mean arterial pressure (MAP) of 5.33-6.67 kPa for 30 min to produce the model of shock. During the shock, the dogs received water-soluble calcium channel blocker Dil or normal saline. The MAP was kept at the level for 90 min, then the total blood which was bled previously was reperfused . They were observed for 240 min. RESULTS: Dil could significantly elevated MAP of the hemorrhagic-shock canines ( P< 0.01) and the activity of superoxide dismmutase (SOD) of pancreas tissue ( P< 0.01),also it could decrease content of malondialdehyde (MDA) of the liver, pancreas and small intestine tissues( P< 0.01). Electron microscope data indicated that Dil-treated dogs have a normal ultrastructure in the liver, pancreas and small intestine tissues. CONCLUSION: Dil can protect the structure and function of the liver, pancreas and small intestine in hemorrhagic-shock canines.