首页 | 本学科首页   官方微博 | 高级检索  
检索        

海水浸泡对火器伤兔肢体骨骼肌组织脂质过氧化反应影响的研究
引用本文:陈蕾,赖西南,陈志强,张良潮.海水浸泡对火器伤兔肢体骨骼肌组织脂质过氧化反应影响的研究[J].中国病理生理杂志,2001,17(6):556-558.
作者姓名:陈蕾  赖西南  陈志强  张良潮
作者单位:重庆第三军医大学大坪医院野战外科研究所,重庆400042
摘    要:目的:观察海水浸泡对火器伤伤口组织脂质过氧化反应的影响。方法:以滑膛枪发射质量250mg钢珠,致伤兔后肢,伤后将致伤兔随机分为两组:一组为海水浸泡组(SIG),将致伤兔浸泡于粗制海盐配制的人造海水中30min;另一组为单纯致伤组(SWG),伤后不浸泡海水。伤后3、6、12、24h手术取距伤道边缘0.5cm(A区)、1.5cm(B区)和2.5cm(C区)处肌组织,测定ATP、丙二醛(MDA)含量和超氧化物歧化酶(SOD)活力。取伤前骨骼肌组织作为对照。结果:伤后SIG兔伤肢骨骼肌MDA含量明显高于对照,伤后3、6h升高,12h略降,24h有再次升高的趋势。SWG的MDA含量变化与SIG相似,但升幅低于SIG;2组SOD活力和ATP含量的改变与MDA含量变化相似。结论:海水浸泡的火器伤伤口脂质过氧化反应增强,从而加重了肢体火器伤的过氧化反应。

关 键 词:创伤  枪击  海水  过氧化脂质类  
文章编号:1000-4718(2001)06-0556-03
收稿时间:2000-01-10
修稿时间:2000年1月10日

The influence of seawater on lipid peroxidation of the muscle tissue wounded by firearm in rabbit limbs
CHEN Lei,LAI Xi-nan,CHEN Zhi-qiang,ZHANG Liang-chao.The influence of seawater on lipid peroxidation of the muscle tissue wounded by firearm in rabbit limbs[J].Chinese Journal of Pathophysiology,2001,17(6):556-558.
Authors:CHEN Lei  LAI Xi-nan  CHEN Zhi-qiang  ZHANG Liang-chao
Institution:Surgery Research Institute, Third Military Medical University, Chongqing 400042, China
Abstract:AIM: The influence of the seawater on the lipid peroxidation of the muscle tissue wounded by firearm was studied. METHODS: Both two limbs of rabbits were wounded by the steel ball of 250 mg. The wounded rabbits were divided into two group: One is seawater immersed group (SIG), which was dipped in artificial seawater for 30 min. Another is the single wounded group (SWG), which wasn't dipped in seawater. Then, muscle tissues 0.5 cm (A area), 1.5 cm (B area) and 2.5 cm (C area) from wound edge were cut for biochemical analysis at 3, 6, 12, 24 h of post-wound, respectively. The contents of ATP, MDA and SOD activity of all these tissues were detected, pre-wounded muscle tissues were used as control group. RESULTS: The content of MDA in SIG increased obviously at 3, 6 h, respectively, but it decreased slightly at 12 h and increased again at 24 h. The change in MDA in SWG is similar to that in SIG but more slightly. The changes in both the activity of SOD and the content of ATP in two groups is similar to that of MDA. CONCLUSION: Seawater induced more serious lipid peroxidation in the muscle tissue wounded by firearm.
Keywords:Wounds    gunshot  Seawater  Lipid  peroxides
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《中国病理生理杂志》浏览原始摘要信息
点击此处可从《中国病理生理杂志》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号