外泌体在缺血性脑卒中的研究进展

正1外泌体概述外泌体是直径在30~100 nm的胞外囊泡,通过细胞被释放到细胞外液中~(1])。它们存在于生物体液中,诸如血液和脑脊液。外泌体携带有DNA、RNA、蛋白质和脂质等。由于外泌体的微泡结构为其内在的小分子提供了一个安全稳定的环境,同时这些信号小分子利用循环系统在胞间信号交换发挥重要作用,这让外泌体表现出一个成熟、稳定的信号传输系统~(2])。研究发现,外泌体中的m RNA和micro RNA

Advance of exosomes in ischemic stroke

Stroke is one of the major causes of death and disability in China and even worldwide. At present, treatment of stroke has been traditionally focused on reducing death of ischemic cells. However, clinical trials have shown that none of neuroprotective drugs tested achieve clinical benefit after acute stroke. Exosomes are 30~100 nm extracellular vesicles derived from cells with cell membrane structure. Many studies suggest exosomes play essential roles in intercellular communication by transferring their cargo between source and target cells in brain. Emerging data show that exsomes also make a contribution to brain recovery via regulating highly interactive process pathway after stroke. Here, we review these advances and highlight the potential therapeutic functions of exosomes in brain remodeling after stroke.