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太子参对心肌梗死后慢性心衰大鼠心功能与基质金属蛋白酶表达的影响
引用本文:沈祥春,陶玲,彭佼,方泰惠.太子参对心肌梗死后慢性心衰大鼠心功能与基质金属蛋白酶表达的影响[J].中国病理生理杂志,2008,24(9):1694-1698.
作者姓名:沈祥春  陶玲  彭佼  方泰惠
作者单位:1贵阳医学院药理研究室, 贵州 贵阳 550004;2南京中医药大学药理教研室, 江苏 南京 210029
基金项目:贵阳医学院博士基金,贵州省科技攻关项目,贵州省科学技术基金
摘    要:目的:研究太子参对心肌梗死诱导的慢性心衰大鼠心功能与基质金属蛋白酶(MMPs)表达和活性的作用。方法:采用结扎大鼠冠状动脉复制急性心肌梗死诱导慢性心衰动物模型,以血流动力学指标分析心功能,RT-PCR分析MMP-2与MMP-9的mRNA表达,酶谱法分析MMP-2与MMP-9的活力。结果:大鼠冠脉结扎6周后,心功能显著紊乱;左心室组织MMP-2与MMP-9 mRNA水平显著提高、酶活力增加。太子参水煎液连续灌胃给药5周,可显著改善心衰大鼠的血流动力学,抑制左心室组织MMP-2与MMP-9的活力和mRNA的水平增加(与模型组比较,差异显著,P<0.01,P<0.05)。结论:大鼠冠脉结扎6周形成慢性心衰模型,太子参水煎液可改善大鼠冠脉结扎所诱导的心衰,其机制可能与MMPs的表达和活性有关。

关 键 词:太子参  心肌梗死  基质金属蛋白酶  血流动力学  
收稿时间:2007-6-6
修稿时间:2007-12-6

Effects of radix pseudostellariae on cardiac function and matrix metalloproteinases in rat chronic heart failure induced by coronary artery ligation
SHEN Xiang-chun,TAO Ling,PENG Jiao,FANG Tai-hui.Effects of radix pseudostellariae on cardiac function and matrix metalloproteinases in rat chronic heart failure induced by coronary artery ligation[J].Chinese Journal of Pathophysiology,2008,24(9):1694-1698.
Authors:SHEN Xiang-chun  TAO Ling  PENG Jiao  FANG Tai-hui
Institution:1Research Division of Pharmacology, Guiyang Medical College, Guiyang 550004, China; 2Department of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China. E-mail:shenxiangchun@126.com
Abstract:AIM:To investigate the effects of radix pseudostellariae on cardiac function and matrix metalloproteinases (MMPs) in rat chronic heart failure induced by coronary artery ligation. METHODS:Rat model of chronic heart failure was produced by ligating the coronary artery for 6 weeks. The cardiac functions were determined by observing the hemodynamics parameters. mRNA expressions of MMP-2 and MMP-9 in left ventricular tissue were detected by RT-PCR and activities of MMPs were assayed by zemography.RESULTS:Cardiac function was remarkable turbulence after coronary artery ligation 6 weeks, according to the results of the hemodynamics. The mRNA contents and activities of MMP-2 and MMP-9 in left ventricular tissue were significantly elevated. Radix pseudostellariae remarkable ameliorated the cardiac functions, inhibited the mRNA contents and activities of MMP-2 and MMP-9 in left ventricular tissue of rat with chronic heart failure after continued 5 weeks treated with decoction of radix pseudostellariae. CONCLUSION:The decoction of radix pseudostellariae ameliorates cardiac functions of rat with chronic heart failure. The mechanism maybe involves in the inhibition of the MMP-2 and MMP-9 mRNA expression and activities in cardiac ventricles.
Keywords:Radix pseudostellariae  Myocardial infarction  Matrix metalloproteinases  Hemodynamics
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