| G蛋白偶联受体30的特点及其在纤维化疾病中的作用机制 |
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| 引用本文： | 洪紫薇,张帅帅,刘金成.G蛋白偶联受体30的特点及其在纤维化疾病中的作用机制[J].中国病理生理杂志,2022(2):370-374. |
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| 作者姓名： | 洪紫薇 张帅帅 刘金成 |
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| 作者单位： | 空军军医大学第一附属医院心血管外科 |
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| 基金项目： | 国家自然科学基金资助项目(No.82070264);陕西省创新人才推进计划(No.2017KJXX-05);陕西省科技资源开放共享平台(No.2019PT-24)。 |
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| 摘 要： | 纤维化是一种组织受到破坏后的修复反应,主要由于炎症因子过度刺激引发实质细胞坏死、细胞外基质(extracellular matrix,ECM)分泌过剩,大量沉积于细胞间质,形成胶原蛋白排列紊乱的病理表现,严重者导致器官结构紊乱和功能障碍,甚至发生器官衰竭1].
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| 关 键 词： | 纤维化 雌激素受体 G蛋白偶联受体30 |
Characteristics of G-protein-coupled receptor 30 and its mechanism in fibrotic diseases |
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| HONG Zi-wei,ZHANG Shuai-shuai,LIU Jin-cheng.Characteristics of G-protein-coupled receptor 30 and its mechanism in fibrotic diseases[J].Chinese Journal of Pathophysiology,2022(2):370-374. |
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| Authors: | HONG Zi-wei ZHANG Shuai-shuai LIU Jin-cheng |
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| Institution: | (Department of Cardiovascular Surgery,First Affiliated Hospital,Air Force Medical University,Xi'an 710032,China) |
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| Abstract: | Fibrotic lesions of all organs show similar histological abnormalities such as decreased parenchymal cells and increased interstitial fibrous connective tissue. Fibrotic lesions may lead to structural abnormalities and functional disorders of organs,and even organ failure. Inflammatory response is the initiating factor of the occurrence and development of fibrotic diseases. Activation of G-protein-coupled receptor 30(GPR30)can exert the anti-inflammatory effect,but the mechanism of GPR30 in fibrotic diseases is still unclear. Here we reviewed the research progress of GPR30 in regulating myocardial fibrosis,liver fibrosis and renal fibrosis. |
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| Keywords: | Fibrosis Estrogen receptors G-protein-coupled receptor 30 |
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