谷胱甘肽硫-转移酶研究进展

谷胱甘肽硫 -转移酶 (ｇｌｕｔａｔｈｉｏｎｅＳ -ｔｒａｎｓｆｅｒａｓ ｅｓ,ＧＳＴｓ)是一组具有多种生理功能的蛋白质 ,主要存在细胞液中。在哺乳类动物各组织中均含有不同种类的ＧＳＴｓ,其含量和活性亦各不相同。其中以肝脏中含量最高 ,约占肝脏可溶性蛋白的 5%。ＧＳＴｓ能催化还原型的谷胱甘肽 (ｇｌｕｔａｔｈｉｏｎｅ,ＧＳＨ)的巯基 ( -ＳＨ)结合到疏水的化合物上 ,使亲电子的化合物变成亲水的物质 ,易于从胆汁或尿液中排泄1 ] 。通过这种方式将体内各种有潜在毒性的物质及亲脂性化合物降解排出。某些ＧＳＴｓ同功酶含有非硒依赖…

Advances in glutathione S-transferases research

Glutathione S-transferases(GSTs) are a family of soluble detoxification enzymes which use reduced glutathione(GSH) in conjugation and reduction reactions.Toxic electrophiles,including a variety of carcinogens,are substrates for the GSTs and are more easily excreted into bile or urine after conjugation or reduction .The three-dimensional structures of GSTs from several species,including humans,have been determined.GST activity has been found to present in all human tissues,and expression of the various GST isoenzymes differs in degree in the various tissues. Glutathione S-transferases may play a role in the protection of cells against toxic electrophiles and in the resistance to cancer chemotherapeutic agants.The polymorphisms of GSTs genes are one of the important factors that exercise influence on individual susceptibility to cancer.