| 细胞自噬在急性肺损伤发展进程中的双刃剑作用 |
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| 引用本文： | 张红,赵自刚,牛春雨.细胞自噬在急性肺损伤发展进程中的双刃剑作用[J].中国病理生理杂志,2020(4):725-734. |
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| 作者姓名： | 张红 赵自刚 牛春雨 |
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| 作者单位： | 河北北方学院微循环研究所;河北医科大学 |
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| 基金项目： | 国家自然科学基金资助项目(No.81770492)。 |
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| 摘 要： | 急性肺损伤(acute lung injury,ALI)是急危重症患者常见的一种器官损伤,肺实质细胞死亡是ALI的基础,明确细胞死亡的发生机制将为防治ALI提供重要的理论支撑1]。细胞自噬(autophagy)是细胞代谢过程中的衰老细胞器和异常蛋白质等成分降解的过程,受多条信号通路与多种信号分子的调节,有利于维持细胞稳态;病理状态下.
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| 关 键 词： | 自噬 急性肺损伤 双刃剑 |
Autophagy functions as a double-edged sword during acute lung injury |
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| ZHANG Hong,ZHAO Zi-gang,NIU Chun-yu.Autophagy functions as a double-edged sword during acute lung injury[J].Chinese Journal of Pathophysiology,2020(4):725-734. |
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| Authors: | ZHANG Hong ZHAO Zi-gang NIU Chun-yu |
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| Institution: | (Institute of Microcirculation,Hebei North University,Zhangjiakou 075000,China;Hebei Medical University,Shijiazhuang 050000,China) |
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| Abstract: | Acute lung injury(ALI)is a severe disease,with high morbidity and mortality. Autophagy dysfunction is involved in ALI induced by different pathogenic factors,manifesting reduced,limited or excessive autophagy levels. Therefore,autophagy functions as a double-edged sword in ALI. Balancing autophagy to the rational level represents a new direction for the prevention and treatment of ALI. |
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| Keywords: | Autophagy Acute lung injury Double-edged sword |
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