P-选择素糖蛋白配体1在肾脏疾病中的研究进展

P 选择素糖蛋白配体1(P selectinglycoprotein ligand 1,PSGL 1)是一种主要表达于白细胞及血小板表面的黏附分子,在免疫识别、炎症反应和血栓形成过程中起着重要作用。慢性肾脏病(chronickid neydisease,CKD)的患病率逐年上升,已成为威胁世界公共健康的主要疾病之一,且其病因复杂,大多数发病机制尚不完全清楚。PSGL 1可通过多种途径参与肾脏疾病的发生发展,其机制可能涉及TGF β1/Smad和PI3K/AKT/GSK 3β等信号通路,以及结缔组织生长因子和C C趋化因子配体2chemokine(C Cmotif)ligand2,CCL2]等肾脏关键调节因子。

Progress of P-selectin glycoprotein ligand-1 in kidney diseases

P-selectin glycoprotein ligand-1(PSGL-1) is an adhesion molecule mainly expressed on the surface of leukocytes and platelets, which plays a vital part in immune recognition, inflammatory response and thrombosis. The prevalence of chronic kidney disease(CKD) is increased gradually and it has been one of major diseases that threaten the world’s public health. In addition, its etiology is complicated, and most of the pathogenesis is incompletely understood. Researches show that PSGL-1 participates in the development of kidney diseases in a variety of ways, and its mechanism may involve signaling pathways such as TGF-β1/Smad and PI3 K/AKT/GSK-3β, as well as key renal regulators such as connective tissue growth factor and chemokine(C-C motif) ligand 2. This review summarizes the research progress of PSGL-1 in renal fibrosis, lupus nephritis, obesity-related kidney disease and acute kidney injury.