脑白质损伤早产儿血清IL-6及NSE的变化及其临床意义

目的了解血清白细胞介素-6（IL-6）及神经元特异性烯醇化酶（NSE）的变化对脑白质损伤早产儿早期诊断的价值。方法观察组为脑白质损伤早产儿35例,对照组为正常早产儿35名。采用ELISA分别于生后1、7、14 d检测两组血清IL-6、NSE水平。结果对照组患儿生后第1、7及14天血清IL-6水平分别为（19.14±1.18）pg/ml、（19.14±1.14）pg/ml及（19.11±1.34）pg/ml,观察组患儿分别为（25.19±3.03）pg/ml、（24.48±2.97）pg/ml及（23.74±2.95）pg/ml,观察组显著高于对照组,差异有统计学意义（P均=0.000）。对照组患儿生后第1、7及14天血清NSE水平分别为（4.70±0.36）ng/ml、（4.31±0.29）ng/ml及（4.14±0.30）ng/ml,观察组患儿分别为（6.30±0.89）ng/ml、（6.05±0.86）ng/ml及（5.64±0.75）ng/ml,观察组显著高于对照组,差异有统计学意义（P均=0.000）。结论脑白质损伤早产儿血清IL-6和NSE的浓度明显高于对照组。监测早产儿血清IL-6和NSE水平,对脑白质损伤的诊断和治疗效果的评价具有一定临床价值。

The levels of IL-6 and neuron-specific enolase in the preterm infants with white matter injury and their clinical significance

Objective To evaluate the significance of interleukin-6（IL-6）and neuron specific enolase（NSE） in early diagnosis of the matter damage in preterm infants.Methods Thirty five preterm infants with white matter injury（WMI） were allocated to the treatment group,and thirty five healthy preterm infants were selected to the control group.ELISA method was taken to measure IL-6 and serum NES levels on the first day,seventh day and fourteenth day after birth.Results The levels of IL-6 in the control group on the 1st,7th and 14th day after birth were（19.14±1.18）pg/ml,（19.14±1.14）pg/ml and（19.11±1.34）pg/ml,respectively,while those in the treatment group were（25.19±3.03）pg/ml,（24.48±2.97）pg/ml and（23.74±2.95）pg/ml,respectively.The levels of IL-6 in the treatment group were significantly higher than those in the control group（P=0.000）.The levels of NSE in the control group on the 1st,7th and 14th day after birth were（4.70±0.36）ng/ml,（4.31±0.29）ng/ml and（4.14±0.30）ng/ml,respectively,while those in the treatment group were（6.30±0.89）ng/ml,（6.05±0.86）ng/ml and（5.64±0.75）ng/ml,respectively.The levels of NSE in the treatment group were obviously higher than those in the control group（P=0.000）.Conclusion The levels of IL-6 and NSE in the preterm infants with white matter injury in the treatment group were higher than those in control group,so it is clinically significant to measure the IL-6 and NSE levels in the preterm infants for the diagnosis of WMI and during its treatment.