粘蛋白MUC1与非小细胞肺癌研究进展

MUC1正常情况下主要表达于多种组织、器官中上皮细胞近管腔或腺腔面,呈顶端分布或极性分布,对正常的上皮起润滑和保护作用,同时还介导信号转导和细胞黏附。在肿瘤组织中MUC1的表达多出现量和质的改变,并与肿瘤的浸润、转移及预后相关。有研究表明它可作为肺癌细胞的分化标志,随着肺癌细胞分化表型趋于成熟,其表达逐渐下降。因此,MUC1可能成为一种非常有价值的肿瘤标志物,用于肺癌的临床诊断、治疗和预后的判断。

Research evolves of MUC1 expression in non small-cell lung cancer

Under normal circumstances,the main expression of MUC1 in a variety of tissues and organs in the glandular epithelial cells near the lumen or cavity surface,was the top distribution or polarity distribution of the normal epithelium from the lubrication and protection,but also mediated signal transduction and cell adhesion.MUC1 in the tumor tissue more than the expression of quantitative and qualitative changes occur,and with tumor invasion,metastasis and prognosis.Research has shown that it can be used as d...