| CD64在急性白血病免疫分型中的意义 |
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| 引用本文： | 饶若,金丽华,王述文,姚红霞.CD64在急性白血病免疫分型中的意义[J].免疫学杂志,2011(10):871-874. |
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| 作者姓名： | 饶若 金丽华 王述文 姚红霞 |
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| 作者单位： | 海南省人民医院血液病研究室; |
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| 摘 要： | 目的探讨CD64在急性白血病免疫分型中的意义。方法应用直接荧光标记法,经流式细胞术对116例急性髓系白血病(AML)和70例急性淋巴细胞白血病(ALL)进行免疫表型的检测。结果 AML组CD64的表达阳性率明显高于ALL组(41.4%vs 2.9%,P<0.01)。CD64在M5和M4的表达阳性率最高,分别为77.1%和55.6%。CD64的阳性表达率在M0(0)、M1(0)、M2(7.9%)明显低于M3(47.1%)、M4与M5(P<0.01)。各亚型CD64阳性病例中,M4、M5的CD64阳性细胞表达率分别为(62.5±24.7)%、(68.7±25.9)%,均明显高于M2(28.3%±5.7%)、M3(34.3%±6.3%)(P<0.01)。CD64对诊断AML的灵敏度优于CD14,其特异度优于CD117、CD33及CD13。虽然CD64诊断M4\M5的特异度较CD14稍差(82.5%vs 100%),但是灵敏度高于CD14(69.8%vs 41.5%)。结论 CD64可作为辅助诊断AML的髓系标志抗原,有助于提高M4/M5的检出率及其与其他AML亚型的鉴别诊断。
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| 关 键 词： | 急性白血病 CD64 免疫分型 |
Significance of CD64 in immunophenotyping of acute leukemia |
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| RAO Ruo,JING Lihua,WANG Shuwen,YAO Hongxia Hematologic Laboratory,Hainan Provincial People's Hospital,Haikou ,China.Significance of CD64 in immunophenotyping of acute leukemia[J].Immunological Journal,2011(10):871-874. |
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| Authors: | RAO Ruo JING Lihua WANG Shuwen YAO Hongxia Hematologic Laboratory Hainan Provincial People's Hospital Haikou China |
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| Institution: | RAO Ruo,JING Lihua,WANG Shuwen,YAO Hongxia Hematologic Laboratory,Hainan Provincial People's Hospital,Haikou 570311,China |
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| Abstract: | This study is assigned to explore the significance of CD64 in immunophenotype of acute leukemia(AL).We used flow cytometry with direct immunofluorescence staining to analyze the immunophenotype of 116 patients with acute myeloid leukemia(AML) and 70 patients with acute lymphoblastic leukemia(ALL).We found that the CD64 positive rate in AML was significantly higher than that in ALL(41.4% vs 2.9%,P<0.01),and demonstrated the highest level in M5(77.1%) and M4(55.6%);the positive rates in M0(0),M1(0),M2(7.9%) w... |
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| Keywords: | Acute leukemia CD64 Immunophenotype |
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