| 黄芪对肺纤维化大鼠Th1/Th2型细胞因子平衡及自由基代谢的影响 |
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| 引用本文： | 刘永琦,李金田,李娟,张毅,颜春鲁,杨军,宋华平.黄芪对肺纤维化大鼠Th1/Th2型细胞因子平衡及自由基代谢的影响[J].免疫学杂志,2009,25(3). |
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| 作者姓名： | 刘永琦 李金田 李娟 张毅 颜春鲁 杨军 宋华平 |
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| 作者单位： | 甘肃中医学院免疫学教研室
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| 基金项目： | 国家教育部春晖计划项目，甘肃省科技人才工程科研资助项目 |
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| 摘 要： | 目的 研究黄芪水提物、黄芪皂苷对博莱霉素(BLM)所致肺纤维化大鼠Th1/Th2型细胞因子平衡、NO、SOD、MDA及肺组织病理结构的影响,探索黄芪阻抑肺纤维化的效应及其机制.方法 Wister大鼠随机分为空白组、BLM模型组、地塞米松组、黄芪水提物组、黄芪皂苷组;气管内注入BLM制作大鼠肺纤维化模型,造模后第2天开始药物干预,14、28 d各取6只大鼠,分别检测血IFN-γ、IL-4、NO水平,肺组织SOD、MDA水平及肺组织病理结构的动态变化.结果 与空白组比较,模型组大鼠IFN-γ、IFN-γ/IL-4比值、SOD含量降低,IL-4、NO、MDA的含量明显升高,肺组织发生明显的肺泡炎及纤维化改变(P＜0.05);与模璎组比较,黄芪水提物组、黄芪皂苷组、地寒米松组使大鼠血IFN-γ、IFN-γ/IL-4比值、SOD含量明显升高,NO、MDA含量明显降低,肺组织的肺泡炎及纤维化程度明显降低(P＜0.05);黄芪水提物组、黄芪皂苷组与地塞米松组比较,各指标均无统计学差异(P＞0.05).结论黄芪水提物、黄芪皂苷对肺纤维化大鼠肺组织均具有保护作用,调节Th1/Th2型细胞因子的平衡及NO代谢、及提高抗氧化能力可能是其阻抑肺纤维化发生的机理之一.
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| 关 键 词： | 肺纤维化 黄芪 细胞因子 自由基 一氧化氮 |
Effects of Astragalus on the balance of Th1/Th2 cytokines and free radical metabolism in rat model of pulmonary fibrosis |
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| LIU Yongqi,LI Jintian,LI Juan,ZHANG Yi,YAN Chunlu,YANG Jun,SONG Hua ping.Effects of Astragalus on the balance of Th1/Th2 cytokines and free radical metabolism in rat model of pulmonary fibrosis[J].Immunological Journal,2009,25(3). |
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| Authors: | LIU Yongqi LI Jintian LI Juan ZHANG Yi YAN Chunlu YANG Jun SONG Hua ping |
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| Institution: | LIU Yongqi,LI Jintian,LI Juan,ZHANG Yi,YAN Chunlu,YANG Jun,SONG Hua ping Department of Immunology,Gansu College of Chinese Traditional Medicine,Lanzhou 730000,China |
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| Abstract: | Objective To observe the effects of Astragalus decoction and Astragalus saponin on the balance of T helper1/T helper2 (Th1/Th2) cytokines,nitric oxide (NO),superoxide dismutase (SOD),malondialdehyde (MDA),and the pathomorphological features in bleomycin (BLM)-induced pulmonary fibrosis rats,and to explore the underlying mechanism. Methods Total of 60 Wister rats were evenly randomized into control,BLM model,Dexamethasone,Astragalus decoction,and Astragalus saponin groups. Pulmonary fibrosis model was establ... |
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| Keywords: | pulmonary fibrosis Astragalus cytokines free radical nitric oxide |
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