Participation of opioid and serotoninergic brain receptors in amphetamine-induced stereotypy and hyperthermy |
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| Authors: | I V Tyurina S K Sudakov |
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| Institution: | (1) Laboratory for Neurobiology of Addictions, Institute for Biomedical Studies of Addiction, State Research Center of Narcology, Ministry of Health of Russia, Moscow;(2) Present address: 3 Malyi Mogil'tsevskii pereulok, 121002 Moscow |
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| Abstract: | The inbred rat strains WAG and Fischer-344 were found to differ in the duration of amphetamine-induced stereotypy and the
degree of hyperthermy elicited by this drug, the stereotypy lasting longer in WAG rats and the hyperthermy being more pronounced
in Fischer—344 rats. A comparison of interstrain differences in the amphetamine effects, in receptor binding, and in the pharmacological
activity of receptor agonists suggests that the μ-opiate system of the brain may be involved in the manifestation of amphetamine-induced
stereotypy, while its serotoninergic system may mediate the elevation of body temperature caused by this drug.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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9, 242–243, September, 1995
Presented by V. N. Yarygin, Member of the Russian Academy of Medical Sciences |
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| Keywords: | amphetamine stereotypy thermoregulation serotonin morphine clonidine |
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