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Comparative analysis of accumulation of chlorine e6 and hematoporphyrin derivatives in subpopulations of peripheral blood lymphocytes
Authors:Email author" target="_blank">V?P?SavitskiiEmail author  V?P?Zorin  M?P?Potapnev  A?Ya?Potapenko
Institution:(1) Republican Research-and-Production Center for Child Oncology and Hematology, Minsk;(2) Belarussian State University, Minsk;(3) Russian State Medical University, Moscow
Abstract:We studied accumulation of porphyrin photosensitizers chlorine e6, hematoporphyrin, and their derivatives by different lymphocyte subpopulations. The intensity of staining of B lymphocytes and natural killer cells with photosensitizers was higher compared to T lymphocytes. T cell subpopulation differed by their ability to bind photosensitizers. Relative accumulation of dimethyl esters of chlorine e6 and hematoporphyrin in cells surpassed that of nonesterified porphyrins. Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 8, pp. 180–184, August, 2004 Thisk work was supported by the Belarussian-Russian Foundation for Basic Research (grant NO. B02R-084).
Keywords:photodynamic therapy  photosensitizers  lymphocytes  accumulation  flow cytometry
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