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Effect of Glucocorticoid Receptor Blockade on Analgesic Effect of Corticotropin-Releasing Factor
Authors:N I Yarushkina  T R Bagaeva  L P Filaretova
Institution:Laboratory of Experimental Endocrinology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. yarni60@mail.ru
Abstract:The role of glucocorticoid receptors in the analgesic effect of corticotropin-releasing factor in rats was studied after glucocorticoid receptor blockade with antagonist RU 38486. Glucocorticoid hormones can potentiate the analgesic effect of corticotropin-releasing factor or modulate the mechanisms of this effect, which depends on the type of painful stimulus.
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