Cytokine-induced differentiation and proliferation of human T lymphocytesin vitro: Effects of interleukin 2 and interleukin 6 |
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| Authors: | V. V. Smol'nikova A. V. Voznyuk M. P. Potapnev |
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| Affiliation: | (1) Institute of Hematology and Hemotransfusion, Ministry of Health of the Belorussia Republic, Minsk;(2) Republical Research and Practical Center of Children Oncology and Hematology, Ministry of Health of the Belorussia Republic, Minsk |
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| Abstract: | The contents of CD8+, CD4+CD8+, CD3+HLA-DR+, CD+INF-γ+ T cells, and natural killers (CD16+56+) and NK/T cells (CD16+56+CD3+) increase after 7-day culturing in the presence of interleukin-2. The number of apoptotic cells and cells in S-, and G2+M phases of the cell cycle also increased. Interleukin-6 predominantly induced proliferation of CD3+HLA-DR+ T cells and G2+M mitotic cells. Translated fromByulleten' Eksperimental'noi Biologii I Meditsiny, Vol. 129, No. 6, pp. 667–671, June, 2000 |
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| Keywords: | interleukin-2 interleukin-6 human T lymphocytes |
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