Effects of various human interleukin-2 preparations and lymphokine-activated killer cells on the production of antibodies in micein vivo and of human immunoglobulinsin vitro |
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| Authors: | M. P. Potapnev T. S. Garbuzenko A. V. Voznyuk E. V. Ruksha O. V. Shadrin S. N. Bykovskaya |
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| Affiliation: | (1) Research Institute of Hematology and Blood Transfusion, Ministry of Health of Belarus, Minsk;(2) Oncological Research Center, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Comparison of the lymphocytic IL-2 (lIL-2, lymphokinin) and recombinant IL-2 (rIL-2) showed that lIL-2 is characterized by a more pronounced stimulating effect of low doses on antibody production in mice and on human immunoglobulin production. High doses of lIL-2, in contrast to rIL-2, do not cause hyperstimulation of antibody production or immunoglobulin production. Human lymphokine-activated killer (LAK) cells, induced by rIL-2in vitro during 7 but not 3 days, enhance the production of human immunoglobulins. Monocytes activated by rIL-2 suppress the stimulating effect of LAK cells on immunoglobulin production. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N o 8, pp. 171–173, August, 1994 Presented by N. N. Trapeznikov, Member of the Russian Academy of Medical Sciences |
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| Keywords: | interleukin-2 lymphokine-activated killer cells humoral immunity |
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