| Abstract: | We studied expression and functional activity of tumor cell P-gp in children with various leukemia variants and analyzed its
prognostic role in acute lymphoblastic leukemia. Functional activity of P-gp increased in acute myeloid leukemia, relapses
of acute lymphoblastic leukemia (in comparison with primary disease), and in a group of patients in whom no remission was
attained. The survival of patients with acute lymphoblastic leukemia was lower in cases with increased expression and function
of P-gp.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 6, pp. 676–680, June, 2006 |
