Comparative Analysis of Accumulation of Chlorine e6 and Hematoporphyrin Derivatives in Subpopulations of Peripheral Blood Lymphocytes |
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Authors: | V P Savitskii V P Zorin M P Potapnev A Ya Potapenko |
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Institution: | Republican Research-and-Production Center for Child Oncology and Hematology, Minsk. savitskiy_v@yahoo.com |
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Abstract: | We studied accumulation of porphyrin photosensitizers chlorine e6, hematoporphyrin, and their derivatives by different lymphocyte subpopulations. The intensity of staining of B lymphocytes and natural killer cells with photosensitizers was higher compared to T lymphocytes. T cell subpopulation differed by their ability to bind photosensitizers. Relative accumulation of dimethyl esters of chlorine e6 and hematoporphyrin in cells surpassed that of nonesterified porphyrins. |
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Keywords: | photodynamic therapy photosensitizers lymphocytes accumulation flow cytometry |
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