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Comparative Analysis of Accumulation of Chlorine e6 and Hematoporphyrin Derivatives in Subpopulations of Peripheral Blood Lymphocytes
Authors:V P Savitskii  V P Zorin  M P Potapnev  A Ya Potapenko
Institution:Republican Research-and-Production Center for Child Oncology and Hematology, Minsk. savitskiy_v@yahoo.com
Abstract:We studied accumulation of porphyrin photosensitizers chlorine e6, hematoporphyrin, and their derivatives by different lymphocyte subpopulations. The intensity of staining of B lymphocytes and natural killer cells with photosensitizers was higher compared to T lymphocytes. T cell subpopulation differed by their ability to bind photosensitizers. Relative accumulation of dimethyl esters of chlorine e6 and hematoporphyrin in cells surpassed that of nonesterified porphyrins.
Keywords:photodynamic therapy  photosensitizers  lymphocytes  accumulation  flow cytometry
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