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Lower body positive pressure increases upper airway collapsibility in healthy subjects
Authors:Su Mao-Chang  Chiu Kuo-Liang  Ruttanaumpawan Pimon  Shiota Satomi  Yumino Dai  Redolfi Stefania  Haight James S  Bradley T Douglas
Institution:The Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, Ontario, Canada.
Abstract:We previously showed that rostral fluid displacement by lower body positive pressure (LBPP) narrows the upper airway (UA) and increases UA resistance, but effects on UA collapsibility remained unknown. To test if LBPP increases UA collapsibility, 13 healthy men were randomized into a control or LBPP arm then crossed over into the other arm with a 30-min washout in between. LBPP was applied by inflating anti-shock trousers wrapped around both legs to 40 mmHg. UA collapsibility was assessed by determining UA critical closing pressure (P crit) during application of different negative airway pressures. P crit and leg fluid volume were measured at baseline and after 5 min during both periods. LBPP caused a significant increase in P crit associated with a reduction in leg fluid volume. We conclude that rostral fluid displacement by LBPP increases UA collapsibility in healthy men, suggesting that fluid shift into the neck could increase UA collapsibility during sleep and thereby predispose patients with fluid overload states to obstructive sleep apnea.
Keywords:Critical closing pressure  Fluid displacement  Lower body positive pressure  Obstructive sleep apnea  Upper airway collapsibility
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