改性甲壳素生物修复膜治疗浅Ⅱ度烧伤的临床疗效

目的探讨改性甲壳素生物修复膜治疗浅Ⅱ度烧伤的临床疗效。 方法将石家庄市第一医院烧伤整形科2016年5月至2018年5月收治的浅Ⅱ度烧伤患者70例按随机数字表法分为治疗组和对照组，每组35例。治疗组患者创面经过碘伏消毒后，外用0.9%氯化钠溶液冲洗，清除坏死腐皮及异物，外用改性甲壳素生物修复膜覆盖，每日换药1次，直至创面愈合；对照组同样清理创面后，外用无菌油纱覆盖创面，每日换药1次。观察伤后7、10、13 d创面愈合率及创面平均愈合时间、患者换药疼痛数字评分法(NRS)评分、创面感染情况、瘢痕情况及其他不良反应。数据比较采用t检验。 结果治疗组患者在伤后7、10、13 d创面愈合率分别为(83.66±3.59)%、(93.69±3.24)%、(99.46±0.78)%明显高于对照组(81.40±3.50)%、(90.63±4.25)%、(98.57±1.63)%，差异均有统计学意义(t＝2.66、3.38、2.90，P＝0.010、0.001、0.006)；治疗组创面平均愈合时间为(12.11±1.89) d，短于对照组(13.51±1.15) d，差异有统计学意义(t＝3.75，P<0.05)；治疗组患者NRS评分为(3.29±0.52)分，低于对照组(3.86±0.49)分，差异有统计学意义(t＝4.72，P<0.05)，2组均未出现感染患者，随访3个月均未发现瘢痕生长，未发现其他不良反应。 结论应用改性甲壳素生物修复膜可提高创面愈合率，缩短浅Ⅱ度烧伤患者创面愈合时间，减轻患者疼痛。

Clinical therapeutic effect of modified chitin bioremediation film in treating superficial partial-thickness burn

ObjectiveTo investigate the clinical therapeutic effect of modified chitin bioremediation film in treating superficial partial-thickness burn. MethodsSeventy cases of superficial partial-thickness burn came from the Department of Burns and Plastic Surgery, First Hospital of Shijiazhuang from May 2016 to May 2018 were randomly divided into the treatment group and the control group according to the random number table method, 35 cases in each group. The wounds of patients in the treatment group were disinfected by iodophor, and then washed with 0.9% sodium chloride solution to remove necrotic skin and foreign bodies, then covered with modified chitin bioremediation film externally, changed dressing once a day until wound healing; the control group also cleaned the wound surface, covered the wound surface with sterile gauze externally, and changed the dressing once a day. The wound healing rate at 7, 10, and 13 days after injury and wound average healing time, the numerical rating scale (NRS) of patients dressing pain, wound infection, scar and other adverse reactions were observed. Data were compared by t test. ResultThe wound healing rate of the treatment group at 7, 10, and 13 days after injury were (83.66±3.59)%, (93.69±3.24)%, and (99.46±0.78)%, which were higher than those of the control group (81.40±3.50)%, (90.63±4.25)%, (98.57±1.63)%, the differences were statistically significant (t=2.66, 3.38, 2.90; P=0.010, 0.001, 0.006); the average healing time of the wound in the treatment group was (12.11±1.89) d, short than the control group (13.51±1.15) d, the difference was statistically significant (t=3.75, P<0.05). The NRS scale in the treatment group was (3.29±0.52) scores, which was lower than that in the control group (3.86±0.49) scores, and the difference was statistically significant (t=4.72, P<0.05). There were no infected patients in the two groups, no scar growth was observed during the follow-up of 3 months, and no other adverse reactions were found. ConlusionThe use of modified chitin bioremediation film can increase the wound healing rate and shorten the healing time of the superficial partial-thickness burn patients, and reduce the pain of patients.