血管生成的调节在瘢痕形成过程中的作用

血管生成的调节主要发生在创面愈合过程中的后2个阶段，即增生期、重塑期。正常情况下，创面形成大量排列紊乱的毛细血管床，但随着创面逐渐愈合，大部分血管凋亡、退化，并重新排列，最终恢复正常皮肤毛细血管结构与密度。该过程受一系列复杂分子及信号通路的调控，主要包括促血管生成和抗血管生成2方面因子的刺激，但关于创面血管功能和毛细血管增生如何影响瘢痕形成的关键问题仍未得到解答。本综述总结国内外现有研究成果，全面阐述创面血管生成的调控机制，深入探讨血管生成和瘢痕形成之间的关系以及血管异常生长影响瘢痕形成的潜在机制，介绍针对血管形成的相关治疗方案，为减少创面瘢痕形成提供新的思路。

Role of angiogenesis regulation in the process of scar formation

The regulation of angiogenesis mainly occurs in the last two stages of wound healing, namely the proliferation stage and the remodeling stage. Under normal circumstances, the wound forms a large number of disordered capillary beds, but with the gradual healing of the wound, most of the blood vessels apoptosis, degradation, and rearrangement, and finally returns to the normal structure and density. This process has been regulated by a series of complex molecules and signal pathways, including angiogenesis and anti-angiogenic factors. However, the questions about how wound vascular function and capillary hyperplasia affect scar formation have not been answered. This review summarizes the existing research results at home and abroad, comprehensively demonstrates the regulatory mechanism of wound angiogenesis, and discusses the relationship between angiogenesis and scar formation, as well as the potential mechanism of abnormal angiogensis affecting scar formation. This paper also introduces the related treatment schemes for angiogenesis, which provides a new idea for reducing scar formation.