长春花碱和细胞松驰素D对肝癌细胞粘弹性的影响

用微管吸吮技术测定了正常肝细胞和肝实质细胞癌细胞的粘弹性，以三参数标准线性固体模型拟实验结果，进一步研究了两种细胞骨架干扰剂处理后肝细胞和肝癌细胞粘弹性系数的变化。

EFFECT OF VINBLASTINE AND CYTOCHALASIN D ON VISCOELASTIC PROPERTIES OF HEPATOCELLULAR CARCINOMA CELLS

Using micropipette aspiration technique, the authors investigated the viscoelastic properties of human hepatocytes and hepatocellular carcinoma (HCC) cells, and the experimental results were fitted with a threeelement standard linear solid model. Further, the authors investigated the change in viscoelastic properties of both hepatocytes and HCC cells by treatments with two drugs. Results showed: The elastic coefficients of HCC cells were obviously higher than the corresponding values of hepatocytes. After treatment with vinblastine and cytochalasin D, the viscoelastic coefficients of HCC cells were significantly lower than those of control. Under the action of vinblastine, the elastic coefficients of hepatocytes increased obviously than those of control, but the viscoelastic properties of hepatocytes treated with cytochalasin D had the same trend of decreasing as that of HCC cells. A breaf discussion was presented about these results.