丝素材料的药物吸附释放性能与调控研究

为了了解丝素材料对药物等的吸附释放性能 ,并探讨对丝素材料的吸附释放性能的调控 ,用不同离子型化合物作为药物模型 ,比较了分别用未修饰和经羧基进行酰胺化修饰后的丝素制作成的多孔丝素凝胶对不同离子型的化合物的吸附释放行为。结果表明 :经修饰后丝素蛋白质的等电点为 pH6 .0左右 ,而天然的为pH4.0左右。未修饰和经修饰的多孔丝素凝胶都随着溶液 pH的上升 ,对阳离子化合物的吸附量增加 ,释放速度减慢 ;对阴离子化合物吸附量减少 ,释放速度加快。但在相同 pH下与未修饰相比 ,经修饰的多孔丝素凝胶所吸附的阳离子化合物的释放速度加快 ,释放量也增加 ;所吸附的阴离子化合物的释放速度和释放量则明显降低。用羧基酰胺化修饰的方法 ,可在一定程度上改变丝素材料对离子型化合物的吸附释放行为

RESEARCH ON DRUG ABSORBING AND RELEASING FUNCTIONS OF FIBROIN AND ITS CONTROL

In order to study the function of fibroin on drug absorption and release and its control, different iontype chemicals were used as drug model. Porous silk fibroin gel made of natural fibroin and fibroin modified by amidation of carboxyl radical were used and functions of absorption and release of different iontype chemicals compared. Results indicated: The isoelectric point of modified fibroin solution was about pH6, but that of natural fibroin solution was around pH4. The releasing speed and amount of cationic type compound absorbed in treated porous fibroin gel were higher than that of the control gel. However, for the behavior of anionic type compound, a significantly different result was observed. The absorption and release behavior of cationic or anionic type compounds in fibroin gels might be changed to a certain extent by the modification of carboxyl radial of fibroin.