婴儿双歧杆菌黑色素瘤靶向性的探讨

目的：探讨婴儿双歧杆菌对黑色素瘤组织的靶向性。方法：用^3H—TdR标记婴儿双歧杆菌，进行放射性体内参入示踪分析；组织切片革兰氏染色，进行图像分析。结果；仅瘤组织内放射性强度随时间延长持续增强，且存在大量革兰氏染色阳性紫蓝色深柒区。结论：婴儿双歧杆菌对黑色素瘤具有一定靶向性。

Investigation on tumor-targeting characteristics of bifidobacterium infantis to melanoma

Objective: To investigate the tumor targeting of Bifidobacterium infantis to melanoma. Methods: After bolus administration of Bifidobacterium infantis with 3H TdR tagged,the radioactivity in tumor and organs were examined along with the time. Immunohistochemical analysis was also taken for examination of distribution of Bifidobacterium infantis in tissues. Results: Radioactivitis in melanoma tissue increased progressively, while the radioactivity in normal organs weakened as times goes on. A large part of area was Gram's positive found in tumor tissue only. Conclusion: Bifidobacterium infantis has tumor targeting characteristics in mice melanoma.