天津市2011-2015年吸毒人群HCV感染状况及影响因素分析

目的 分析天津市2011-2015年艾滋病哨点监测中吸毒人群HCV感染状况及影响因素,为制定相关控制措施提供依据.方法 2011-2015年4-6月对新进入监管场所的吸毒者进行问卷调查并采集血液进行相关血清学检测,通过多因素分析探索该人群HCV感染的影响因素.结果 2011-2015年每年监测调查对象400人,五年共监测2000人.检出HCV阳性1039例,检出率52.0％,HCV感染率从201 1年的64.3％下降到2015年的35.0％ (X2=136.876,P=0.000).多因素分析结果表明与HCV感染有关的因素为年龄(OR=1.700,95％CI:1.463～1.975)、毒品类型(OR=0.510,95％CI:0.425～0.613)与注射毒品(OR=6.468,95％CI:4.600～9.095).结论 天津市吸毒人群HCV感染呈现下降趋势,但是总体来说感染水平较高,急需采取有效措施控制吸毒人群中HCV的感染.

HCV infection status and associated factors among drug users in Tianjin from 2011 to 2015

Objective To analyze the hepatitis C virus infection status and the influencing factors among drug users (DUS) at the HIV sentinel surveillance sites in Tianjin from 2011 to 2015,so as to provide reference for prevention of HCV among them.Methods Sentinel surveillance programs were conducted between April and Juneannually from 2011 to 2015.During this period of time a cross-sectional survey with a face to face interview was conducted among DUS who entered the drug rehabilitation center and the blood samples were collected to test HCV.Multivariate logistic regression analysis was used to analyze the relationship between the infection of HCV and drug abuse behavior.Results Four hundred DUS were surveyed annually,and a total of 2000 DUS were included in the study within the 5 years.The positive rate of HCV infections was 52.0％ (1 039/2 000) among the drug users,and the HCV infection rate declined from 64.3％ in 2011 to 35.0％ in 2015 (trend x2=136.876,P=0.000).Binary logistic regression analysis showed that the factors associated with HCV infections among DUS included age (OR=1.700,95％CI:1.463-1.975),type of drugs (OR=0.510,95％CI:0.425-0.613) and injecting drug (OR=6.468,95％CI:4.600-9.095).Conclusions The rate of HCV infection among DUS showed a downward trend,butit was still high,so there are urgent needs to carry out effective methods to control HCV transmission among DUS.