他汀类药物与急性缺血性卒中

他汀类药物的非降脂作用已得到越来越多的临床试验证实.近来的临床观察发现,缺血性卒中发病前和急性期使用他汀类药物可限制神经功能缺损的严重程度、降低病死率和改善预后;而长期使用他汀类药物者突然停药,可加重卒中损害,增高复发风险.虽然使用他汀类药物可能轻微增高出血风险,但毫无疑问,使用他汀类药物已成为防治缺血性卒中的最重要手段之一.

Statins and Acute Ischemic Stroke

An increasing numaber of clinical trials have confimed the cholesterol-independent effects of statins.Recent clinical observations have found that using statins before the onset of ischemic stroke and during the acute stage can greatly lessen the severity of neurological defi-cits,reduce the mortality,and improve the prognosis;and that for patients with long-term statius treatmem,who withdraw the drug abruptly,may aggravate stroke lesions,and increase the risk of relapse.Although the use of statius may slightly increase the risk of bleeding,undoubtedly,the use of statins has become one of the most important approaches in the prevention and treatment of ischemic stroke.