小儿呼吸机相关性肺炎病原菌分布及耐药性分析

目的分析小儿呼吸机相关性肺炎(VAP)的病原菌分布及药物敏感性。方法对38例VAP患儿的118份标本进行病原菌类型及药物敏感性分析。结果 118例下呼吸道标本分离出病原菌78株,其中革兰阴性菌44株,革兰阳性菌32株,真菌2株。万古霉素的敏感性最高,其次为替卡西林钠-棒酸钾、亚胺培南西司他丁钠和左氧氟沙星,头孢呋辛、阿奇霉素和哌拉西林敏感性最低。结论 VAP病原菌以革兰阴性菌和金黄色葡萄球菌为主,且耐药率较高,根据药敏试验结果选择合适的抗生素是治疗VAP的关键。

Distribution and drug resistance of pathogenic bacterium in children with ventilator associated pneumonia

Objective To analyze the distribution and drug sensitivity of pathogenic bacterium in children with ventilator associated pneumonia(VAP).Methods The distribution and drug sensitivity of pathogenic bacterium of one hundred and eighteen samples from thirty-eight children with VAP was analyzed.Results Seventy-eight pathogenic bacterium were isolated from one hundred and eighteen lower respiratory tract samples,among these,forty-four cases were Gram-negative bacteria,thirty-two cases were Gram-positive bacteria,two cases were eumycete.The sensitivity of vancocin was the highest,followed by licarcillin sodium-potassium clavulanate,imipenem-cilastatin sodium and levofloxacin;the sensitivity of zinacef,azithromycin and piperacillin was lowest.Conclusion The main pathogenic bacterium of VAP are Gram-negative bacteria and staphylococcus aureus with high drug resistance.The choice of suitable antibiotics according to the result of drug sensitivity test is the key to the treatment of VAP.