肺表面活性物质治疗晚期早产儿呼吸窘迫综合征疗效观察

目的探讨肺表面活性物质治疗晚期早产儿呼吸窘迫综合征(RDS)的疗效。方法 74例晚期早产儿RDS分为2组,对照组36例给予机械通气、预防感染和脑损伤、肠内和肠外营养支持等治疗,观察组38例在此基础上给予肺表面活性物质气管内滴入治疗;2组患者分别于治疗前及治疗6、24、48 h进行血气分析,并判定疗效。结果 2组临床疗效比较差异无统计学意义(P>0.05);2组患儿治疗前动脉血气分析指标比较差异均无统计学意义(P>0.05),2组患儿治疗后动脉血气分析指标均有显著改善(P<0.05,P<0.01),观察组改善更显著(P<0.05)。结论肺表面活性物质治疗晚期早产儿RDS可以有效改善低氧血症。

Effect of pulmonary surfactant on late preterm infants with respiratory distress syndrome

Objective To explore the curative effect of pulmonary surfactant in treatment of late preterm infants with respiratory distress syndrome(RDS).Methods Seventy-four late preterm infants with RDS were divided into two groups.Thirty-six patients in control group were treated with mechanical ventilation,infection prevention,prevention of brain injury,enteral and parenteral nutrition;based on this,thirty-eight patients in observation group were treated with pulmonary surfactant through intratracheal instillation.The blood gas analysis was performed before treatment and six,twenty-four,forty-eight hours after treatment in two groups;and the curative effect was evaluated.Results There was no significant difference in the clinical effect between two groups(P>0.05).Before treatment,there was no significant difference in the indexes of arterial blood gas analysis between two groups(P>0.05).After treatment,the index of arterial blood gas analysis improved significantly in two groups(P<0.05,P<0.01),but the improvement was more in observation group(P<0.05).Conclusion Pulmonary surfactant can effectively improve hyoxemia in late preterm infants with RDS.