AECOPD患者炎症相关指标检测及临床意义

目的 探讨慢性阻塞性肺疾病急性加重期（AECOPD）患者CRP、IL-6、IL-8、TNF-α等相关炎症指标的变化及临床意义.方法 选取AECOPD患者及稳定期患者各60例,检测血清及诱导痰液中CRP、IL-6、IL-8、TNF-α水平.结果 AECOPD患者外周血WBC计数、血清CRP、IL-6、IL-8、TNF-α,诱导痰液中IL-6、IL-8、TNF-α,浓度明显高于稳定期患者（P〈0.05）;AECOPD患者治疗后WBC、血清CRP、IL-6、IL-8、TNF-α浓度与治疗前比较明显下降（P〈0.05）.结论 AECOPD患者血清及诱导痰液中的IL-6、IL-8、TNF-α,血清WBC及CRP,均较稳定期患者明显升高,检测相关炎症指标有助于判断患者病情变化及预后.

Detection of inflammation-related indicators of AECOPD patients and its clinical significance

Objective To investigate the changes of the levels of CRP, IL-6,IL-8 and TNF-α in AECOPD patients and their clinical significance. Methods The study selected 60 AECOPD patients as the observation group and 60 COPD patients at stable stage as the control group. Their levels of CRP, IL-6, IL-8, and TNF-α in serum and induced sputum were detected. Results The levels of WBC, CRP, IL-6, IL-8, and TNF-α CRP in serum and induced sputum were obviously higher in the observation group than in the control group （P 〈 0.05）. After the treatment, the serum levels of CRP, IL-6, IL-8, TNF-α decreased significantly （ P 〈 0. 05 ）. Conclusion The levels of CRP, IL-6, IL-8, and TNF-α in serum and induced sputum are relatively higher in AECOPD patients than in COPD patients at stable stage. The detection of the inflammation-related factors can help to evaluate the patients＇ condition change and prognosis.