瑞香属植物化学成分及药理活性研究进展

瑞香属植物药用资源丰富,在我国应用广泛,历史悠久,大多以全草、地上部分或根入药,生物活性强,近年来其化学成分及药理活性的研究引起了国内外研究学者的广泛关注。为更好的对该属植物进行研究及开发利用,通过仔细查阅国内外各大数据库,综述了近5年来关于瑞香属药用植物化学成分及药理活性的最新研究进展,结果表明瑞香属植物中主要含有香豆素类、黄酮及双黄酮类、萜类、木脂素类等多种成分,最新发现100余种化学成分,并详细介绍了其化学结构。最新药理研究成果证实该属植物具有高效的抗HIV、抗肿瘤、抗炎抑菌、抗病毒、抗氧化、免疫调节等多种活性,为明确其药效成分以及作用机制提供参考和依据。

Research Progress on Chemical Constituents from Plants of Daphne and Their Pharmacological Activities

Plants of Daphne have rich medicinal resources in our country, and they have been widely used with a long history. Most of them are made into medicine with the entire plant, overground parts or roots, with broad pharmacological activities. The researches on their chemical components and pharmacological activities have obtained wide attention from scholars from abroad and at home in recent years. In order to further study, develop and utilize this kind of plant, the latest research progresses on chemical constituents and pharmacological activities of Daphne in recent 5 years were reviewed in this article by carefully accessing the major databases at home and abroad. The results showed that the plants of Daphne contained a variety of effective chemical constituents, mainly including coumarins, flavonoids and biflavonoids, terpenoids, lignins. More than 100 kinds of chemical constituents were newly discovered, and their structures were introduced in detail. The latest pharmacological studies indicated that the plants of Daphne had efficient anti-HIV, anti-tumor, anti-inflammatory, antibacterial, anti-viral, antioxidant, immunomodulatory and many other activities, providing references and evidences to clarify their medicinal ingredients and the mechanism of action.