血浆S100蛋白在体外循环术后脑损伤评价中的意义

目的：探讨血浆S100蛋白在体外循环术中和术后脑损伤评价中的意义。方法：体外循环下心内直视手术病人40例，在体外循环中和结束后不同时间点采血测定血浆S100浓度，并观测病人术后精神神经系统并发症。结果：体外循环可引起病人血浆S100蛋白明显升高，水平最高的3例术后均出现明显的精神神经系统症状，术后24～48h无精神神经并发症者血浆S100蛋白恢复到术前水平。结论：体外循环引起的血浆S100蛋白水平变化对体外循环术后脑损伤的评价具有重要意义。

Significance of serum S100 protein in the evaluation of cerebral injury after cardiopulmonary bypass

Objective: To discuss the values of serum S100 protein in evaluating the cerebral injuries during and after cardiopulmonary bypass (CPB). Methods: 40 patients (25 valve replacement, 13 simple congenital heart disease, 2 valve replacement plus CABG) were studied. Serum S100 protein was serially assessed at different time intervals and the patients' neuropyscological complications were recorded. Results: S100 was not detected before CPB, and it reached its peak level at the termination of CPB, then gradually decrease to the preoperative levels. Three patients with the highest level appeared neuropyscological mobidity. Conclusion: S100 protein has significant change during CPB, and may reflect both the severity of the cerebral injury and increased permeability of the blood brain barrier. Its level has very great significance in evaluating cerebral injuries.