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老年高血压患者NT-proBNP水平与肾脏功能关系研究
引用本文:孙晓楠,肖文凯,叶平,吴红梅. 老年高血压患者NT-proBNP水平与肾脏功能关系研究[J]. 解放军保健医学杂志, 2010, 0(1): 16-18
作者姓名:孙晓楠  肖文凯  叶平  吴红梅
作者单位:解放军总医院南楼心血管二科;
基金项目:北京市自然科学基金(7102142);;解放军总医院苗圃基金(7102142)
摘    要:
目的研究血中氨基末端脑利钠肽前体(amino-terminal propeptide of B-type natriuretic peptide,NT-proBNP)与老年高血压患者肾脏功能之间的关系。方法对符合入选条件的258例老年高血压患者进行NT-proBNP水平测定,根据肌酐水平估测肾小球滤过率(estimated glomerular filtration rate,eGFR),比较不同肾功能状态患者NT-proBNP水平并进行相关分析,在此基础上建立直线回归方程。结果肾功能减退患者NT-proBNP水平增加,尤其是eGFR〈60ml/(min·1.73m2)患者proBNP水平明显增高(P〈0.05);NT-proBNP与eGFR明显负相关(相关系数-0.144,P=0.03);多元直线回归分析结果显示,随着eGFR的逐步降低,NT-proBNP水平逐渐增高(β=-0.146,t=-2.244,P=0.026)。结论在老年高血压患者中NT-proBNP水平变化能够反映高血压患者肾脏功能状态的变化,可作为高血压健康管理的动态随访指标。

关 键 词:高血压  氨基末端脑利钠肽前体  肾小球滤过率  老年

Study to evaluate the relationship between NT-proBNP and renal function in elderly hypertension patients
SUN Xiao-nan,XIAO Wen-kai,YE Ping,et al. Study to evaluate the relationship between NT-proBNP and renal function in elderly hypertension patients[J]. Journal Of Health Care And Medicine in Chinese Pla, 2010, 0(1): 16-18
Authors:SUN Xiao-nan  XIAO Wen-kai  YE Ping  et al
Affiliation:the 2nd Department of Cardiology;Southern Building Clinic Division;PLA General Hospital;Beijing 100853;China
Abstract:
Objective This study was designed to investigate the correlation among NT-proBNP and renal function in elderly patients with hypertension so as to evaluate its role in hypertension health management.Methods Serum prosome brain natriuretic peptide(proBNP)levels were determined and renal function was evaluated by estimated glomerular filtration rate(eGFR) which calculated by cock-croft formula in 285 elderly patients with hypertension,correlations and liner regression were drawn between proBNP values and eGFR...
Keywords:Hypertension  Prosome brain natriuretic peptide  Glomerular filtration rate  Elderly  
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