| 拉米夫定治疗中乙肝病毒多聚酶YMDD变异对患者临床经过的影响 |
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| 引用本文： | 闫杰,王磊,徐皖苏,张照华,杜以真,王耀宗.拉米夫定治疗中乙肝病毒多聚酶YMDD变异对患者临床经过的影响[J].山东大学学报(医学版),2001,39(2):171-172. |
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| 作者姓名： | 闫杰 王磊 徐皖苏 张照华 杜以真 王耀宗 |
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| 作者单位： | 1. 山东大学医学院传染病学教研室
2. 济南市传染病医院 |
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| 摘 要： | 研究乙肝病毒(HBV)多聚酶YMDD变异后HBVDNA复现对慢性HBV感染患者临床经过的影响。方法用mpPCR-RFLP技术检测24例拉米夫定治疗过程中出现HBVDNA复现的患者血清，对YMDD变异者的系列临床资料，应用SAS软件进行统计学分析。结果检出YMDD变异18例；YMDD变异后转氨酶水平较HBVDNA转阴时有显著升高，并反跳至治疗前水平。结论出现YMDD变异后，部分病例可有类似肝炎发作、甚至肝脏失代偿的表现。
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| 关 键 词： | 拉米夫定 肝炎病毒，乙型 DNA |
| 文章编号： | 1000-0496(2001)02-0171-03 |
| 修稿时间： | 2000年11月15 |
EFFECT OF HEPATITIS B
VIRUS POLYMERASE YMDD VARIATION ON THE PATIENTS WITH CHRONIC HEPATITIS B TREATED WITH
LAMIVUDINE |
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| YAN Jie,WANG Lei,XU Wan su,et al.EFFECT OF HEPATITIS B
VIRUS POLYMERASE YMDD VARIATION ON THE PATIENTS WITH CHRONIC HEPATITIS B TREATED WITH
LAMIVUDINE[J].Journal of Shandong University:Health Sciences,2001,39(2):171-172. |
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| Authors: | YAN Jie WANG Lei XU Wan su |
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| Abstract: | Objective:To study the effect of HBV polymerase YMDD variation on the patients with chronic hepatitis B treated with lamivudine.Methods:YMMD variation was detected by mispairing PCR RFLP assay.The clinical data of patients with YMDD variation were collected and analysed with SAS software.Results:Of 24 patients with HBV DNA breakthrough during lamivudine therapy,18(75%)had YMDD variations in HBV P gene.ALT and AST levels after YMDD variation changed more highly than before YMDD variation,and increased to the levels before lamivudine therapy.Conclusion:YMDD variation can result in hepatitis outbreak in some patients and even incompensation in severe cases. |
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| Keywords: | Lamivudine Hepatitis B virus DNA |
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